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"Cannabidiol: Barriers to Research and Potential Medical Benefits"

Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.



Background

To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
CBD Biology and Therapeutic Rationale




Ongoing CBD Research

The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:

Treatment of substance use disorders (opioids, alcohol, cannabis, methamphetamine)
Attenuation of the cognitive deficits caused by THC
Neuropathic pain due to spinal cord injury
Mitigating the impact of cannabis use on risk for schizophrenia
Examination of the potential of CBD as an antiepileptic treatment

It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area.

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4. Because of our gentle refining process, our CBD isolate molecules are not damaged or weakened by any harsh chemicals or grueling refining process - unlike our competitors.?
The best predecessors for cannabis are the most fertilized winter cereals, sugar beet, potatoes, corn, grain legumes for grain or green fertilizer. In areas of sufficient moisture or when growing cannabis on irrigated lands, the recommended predecessors are also perennial legumes.

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Cannabinoids are chemical compounds that affect neurotransmitters in the brain. There are More than 81 Active known cannabinoids in cannabis, and cannabidiol (CBD) is one that has been receiving a lot of medical and scientific attention. Why is that the case? Well, whereas marijuana contains a high amount of THC (the chemical responsible for the "high" or "stoned effect"), CBD can be derived from the hemp plant in high concentrations, with virtually no THC. Marijuana is a cannabis plant bred for high THC concentrations and hemp is now being bred for high CBD concentrations, but almost zero THC levels, and certainly below the illegal amounts. Which makes hemp CBD products safe as a medicinal aid for all ages and lifestyle needs. Ask any "stoner" or marijuana enthusiast why they're pro-cannabis and you'll end up with a myriad of answers. However, the top two are generally based on the "zoning out" or relaxing properties of the THC, and the natural element - meaning it's among the safest recreational substances available. But marijuana is still a drug by definition, and it is still addictive with continued use. However, CBD derived from hemp isn't addictive because of its anti-psychoactive properties. Yet its medical properties are still impressive when used correctly. How Does Cannabidiol Help Athletes? Lately, athletic associations and individual fitness fanatics have gotten on the CBD wagon. This goes beyond the common practice of smoking a joint to steady nerves before a big game. Science has proven that Hemp-based CBD reduces pain, inflammation, and muscle spasm. But that's not all. Properly taken, CBD derived from hemp also reduces nausea and helps with sleep patterns or insomnia. But perhaps the biggest scientific result deals with CBD's effect on the brain. Unlike THC which causes the brain chemistry to change and crave more of the drug itself, CBD (cannabidiol) actually protects the brain's neurological function and improves healing speed after concussive injuries. While it may sound like a miracle cure, it's very close. High-quality CBD must be taken properly and with proper intent to work correctly. But when those guidelines are met, post-routine CBD use can be tremendously effective for reducing athletic-related injuries and improving the healing process so you can get back to the game, and as always, please share these articles with others.
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Method of production: Cold pressing Used part of the plant: seeds

Scott Sizer was diagnosed with multiple sclerosis in 1990. He uses a wheelchair and has regular muscle spasms.
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That classification is being challenged in a federal appeals court in San Francisco, and so far the feds have shown little interest in cracking down on CBD sellers.


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